Metal-enhanced emission from indocyanine green: a new approach to in vivo imaging.

نویسندگان

  • Joanna Malicka
  • Ignacy Gryczynski
  • Chris D Geddes
  • Joseph R Lakowicz
چکیده

Indocyanine green (ICG) is widely used in medical imaging and testing. Its complex spectral behavior and low quantum yield limits some applications. We show that proximity of ICG to a metallic silver particle increases its intensity approximately 20-fold and decreases the decay time. Since the rate of photobleaching is not increased, our results suggest that ICG-silver particle complexes can yield at least 20-fold more photons per ICG molecule for improved medical imaging.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Comparative Studies of High Contrast Fluorescence Imaging Efficiency of Silica-coated CdSe Quantum Dots with Green and Red Emission

Herein we report the possibility of using green and red emitting silica-coated cadmium selenide (CdSe) quantum dots (QDs) for remarkable stem and cancer cellular imaging, efficient cellular uptake and fluorescence imaging of semi and ultra-thin sections of tumor for in vivo tumor targeted imaging applications. The comparative studies of high contrast cellular imaging behaviours of the silica-co...

متن کامل

Photosensitivity and Radiosensitivity of Indocyanine Green on Human Cell Lines MCF7 and DFW

Background & Aims: In this study with the aim of benefiting from non-laser sources in photodynamic therapy, photo and radio sensitivity of indocyanine green as a sensitizer in photodynamic and radiation therapies were investigated. Methods: Based on the broad absorption peak of indocyanine green and using non-coherent light, the experiments were performed on human cells derived from breast canc...

متن کامل

Effects of Metallic Nanoalloys on Dye Fluorescence

Metallic nanoparticles (NPs) are exploited for their ability to interact with organic compounds and to increase significantly the fluorescence intensity and the photostability of many fluorescent dye molecules. Metal enhanced fluorescence (MEF) is therefore widely investigated for biosensing applications. When used in immunoassays, silver island films (SIFs) could augment the fluorescence inten...

متن کامل

Development of photostable near-infrared cyanine dyes.

With the emerging interest in optical in vivo imaging, there is an increasing demand of photostable near-infrared (NIR) dyes. Herein we report the rational design of an amine tricarbocyanine structure with improved photostability (CyNA) and its combinatorial derivatization to render CyNA-414 as a NIR-fluorescent dye with stronger emission intensity and higher photostability than the NIR standar...

متن کامل

In-House Handmade Camera for Indocyanine Green Video Angiography

Background and Aim: Vascular imaging during surgical procedures is very important and has many applications.  There are several methods for intraoperative vascular assessment such as intraoperative angiography, Doppler, and fluorescence-based techniques. The latter group and specially the Indocyanine Green (ICG) Video Angiography (VA) is commonly used for vascular surgery and sentinel node...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Journal of biomedical optics

دوره 8 3  شماره 

صفحات  -

تاریخ انتشار 2003